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KMID : 0388419930030010109
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Konkuk Journal of Medical Sciences
1993 Volume.3 No. 1 p.109 ~ p.114
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A Clinical Study on the Hypotensive Effect of Captopril and Nifedipine
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이영수
주용진/김준호/공수정/정상만/문언수/정시전
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Abstract
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Background:
@EN The hypotensive effect of captopril(angitensin converting enzyme inhibitor) and nifedipine(calcium channel blocker) was studied.
@ES Method:
@EN Captopril(75mg) and nifedipine(39mg) were administered in 30 hypertensive adults during twelve weeks after a week observation for washout with stepwise increments of the dose according to the patients' blood pressure in every two weeks.
@ES Result:
@EN The supine blood pressure were decreased from 169.5±22.3/104.0±20.3 mmHg to 130.4±21.3/82.4±19.5mmHg at the end of twelve weeks during therapy. (p<0.05)
The standing blood pressure were also decreased conferrably and to the some lower level. Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment.
During the period of the study a few probably drug-related symptom such as cough and headache. gastrointestinal disturbance developed but not troublesome enough to administering.
@ES Conclusion:
@EN Captopril and nifedipine regimen is well tolerated and effective in the treatment of hypertensive patients.
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KEYWORD
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